Glial function (and dysfunction) in the normal & ischemic brain
نویسندگان
چکیده
منابع مشابه
Optogenetic Countering of Glial Acidosis Suppresses Glial Glutamate Release and Ischemic Brain Damage
The brain demands high-energy supply and obstruction of blood flow causes rapid deterioration of the healthiness of brain cells. Two major events occur upon ischemia: acidosis and liberation of excess glutamate, which leads to excitotoxicity. However, cellular source of glutamate and its release mechanism upon ischemia remained unknown. Here we show a causal relationship between glial acidosis ...
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Attributable to their strong electrical activity, neurons have long been seen as the main determinants of brain function. Over the last decades, however, this view changed dramatically. A variety of specific roles have been assigned to different types of glial cells. Astrocytes constitute the link between the vascular system and neighboring neurons. They determine ion and transmitter homeostasi...
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ژورنال
عنوان ژورنال: Neuropharmacology
سال: 2018
ISSN: 0028-3908
DOI: 10.1016/j.neuropharm.2017.11.009